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Pueraria mirifica


Local communities in Thailand have used Kwao Kreu Kao (pueraria mirifica) for generations for its rejuvenating qualities.
In May 1931, Luang Anusan Suntara published a pamphlet on the subject of kwao Kreu describing different ways of preparing
folk herbal remedy using Kwao Krua (pueraria mirifica) and the claims of it's rejuvenating power.
It is stated in the pamphlet that pueraria mirifica can;

Serve as the fountain of youth for aged men and woman.

Serve as a anti-wrinkle agent for aged and wrinkled skin.

Darken white hair and increase hair growth.

Alleviate cataract problems.

Help with memory loss.

Increase energy and vigor, more reflexive bodily movements.

Increase blood circulation.

Increase appetite.

Alleviate sleep disorders.

In 1932, Dr. A.F.G. Kerr, the Director of the Botanical Section of the Journal of the Siam Society,
directed the attention of the scientific community to the fact that the tuberous roots of a Thai plant called
Kwao Krue originally mistakenly identified as Butea Superba, were considered to be of value as a rejuvenating herb.
Dr. Kerr was the first to create international awareness of the rejuvenating qualities of this plant which subsequently
led to the isolation of a potent phytoestrogen that is unique to this plant and to the identification of the plant
as Pueraria Mirifica in 1952.

More detailed information on how Pueraria mirifica works with female hormone receptors

According to research this herb contains phytoestrogens that can exert protective hormonal effects similar to estriol. Estriol is known as a very protective estrogen. There is a lack of evidence that estriol would be cancer promoting, but instead is cancer prohibiting. These same protective benefits are not reported with estrone or estradiol, two of the more abundant and potent forms of estrogen in the body.

Pueraria Mirifica attaches to estrogen receptors, making more harmful effects of estrogens ineffective. In fact, according to an article published in 2007 by the Health Sciences Institute stated, “Pueraria Mirifica doesn’t simply mimic estrogen in the body the way that other therapies do, whether bio-identical or not. Instead, the herb (much like the human byproduct it resembles) acts on estrogen receptors. In more clear terms, it acts as a balancing agent: When levels of estrogen are too high, Pueraria Mirifica will tie up receptors to weaken the hormone’s effects – when levels are low, the herb exerts the necessary estrogenic activity without actually increasing the amount of estrogen in your body.

As a result, your hormones are modulated and signs of aging linked to your body’s numerous estrogen-receptors (whether it’s menopausal symptoms, wrinkles, balding, or graying hair) are halted or reversed. And without any risk of toxicity, either”. Current scientific research recognizes that there are two types of estrogen cell surface receptors, the alpha receptor (ERa) and beta receptor (ERb). ERa affects classical, estrogen sensitive tissues, e.g., breasts, uterine endometrium, ovarian stromal cells, male testes and vas deferens, and the hypothalamus in the brain.

Whereas, ERb affects non-classical, estrogen sensitive tissues, e.g., brain, bone, heart, lungs, kidneys, intestinal mucosa, and vascular endothelium in both sexes. Excessive ERa stimulation can lead to breast cancer and other estrogen-dependent cancers. Competitive inhibition of ERa receptors by phytoestrogens, via blocking the binding of the stronger, estrogenic hormones, i.e., estrone and estradiol, can help protect against the development of estrogen-dependent cancers of the breast, uterus, ovaries and prostate.

This is the physiochemical basis for the anti-carcinogenic effect of soy isoflavones, and various other naturally occurring phytoestrogens. Phytoestroegns from various plant sources may either activate or inhibit ERa and/or ERb receptors. Miroestrol and deoxymiroestrol in Pueraria preferentially powerfully stimulate ERb receptors, and inhibit ERa receptors.

Miroestrol and its derivatives are known to be approximately 3,000 times more potent than soy isoflavones with respect to estrogen receptor effects. ERb stimulation in the brain has been shown to protect neuronal cells from injury and death from excitotoxins, e.g., MSG. ERb stimulation in the prostate gland helps protect against hyperplasia, and reduce symptoms of benign enlargement of the prostate. Pueraria mirifica may constitute a new class of safe, non-toxic, effective, hormonal therapeutic support as natural, Selective Estrogen Receptor Modulators (SERMs), with estrogen agonist activity in certain tissues and antagonist activity in others, which help balance hormonal function, and possess significant, anti-aging, protective properties for estrogen sensitive tissues in both men and women.

Research studies on miroestrol and deoxymiroestrol in Pueraria have demonstrated: strong anti-mutagenic properties anti-carcinogenic effects, esp. among breast cancer and colon cancer lines relatively safe control of perimenopausal and postmenopausal symptoms, i.e., vasomotor instability, hot flashes, night sweats, and mood changeability, similar to effects exhibited by conjugated equine estrogens, but without the toxicity prevention and improvement of osteopenia and osteoporosis in both sexes significant improvement of blood lipid and cholesterol levels enhanced function of the endothelial lining of blood vessels cardiovascular protective properties prevention and reduction of prostate hyperplasia prevention and reduction of erectile dysfunction mammogenic effects, i.e., natural promotion of enlargement, toning and firming of the female breasts, by stimulating healthy, breast gland fibroblastic activity

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